Dont Mix Ambien and Vicodin.

SunflowaSeeds

Yes you can take these 2 but limit your dosage. I take 10mg vicdins 4 xs a day as prescribed and also a 10mg ambien at night for sleeping and have never had a problem. I am prescribed both by my DR. so it limited doses under doctors supervision u can.
•NO you CANNOT mix these two drugs! VICODIN IS A NARCOTIC PAIN reliever, not one of the strongest, but it is a CNS (central nervous system) depressant. As far as the sleeping pill- it makes a difference if it is a barbiturate (Halcion, Chloral hydrate, which are also CNS depressants) OR a hypnotic (Ambien, Rozeram) which are not CNS depressants. You need to be VERY careful if you combine two drugs that are both CNS depressants. You should ask your doctor OR call ANY pharmacy and ask to speak to a pharmacist. Give them the names of the medications and dosages, and they will tell you if there is a problem, (called a DRUG/DRUG INTERACTION). Many times pharmacists have more up to date, accurate information about drugs that CAN be taken together V.S. drugs that can NOT be taken together


•Ambien is NOT a CNS depressant i dunno wtf it does really i just know that personally i have taken up to 50mg of vicodin in a day then still take a ambien 10mg at night and it works fine... opiates like vicodin have been know to actually keep people awake.I wouldnt worry just dont take more than 10mg of ambien

riddlerap

Insomnia


Zolpidem Tartrate 10 MG tablets
Zolpidem is approved for the short-term (usually about two to six weeks) treatment of insomnia, and it has been studied for nightly use up to six months in a single-blind trial published in 1991,[13] an open-label study lasting 180 days published in 1992 (with continued efficacy in patients who had kept taking it as of 180 days after the end of the trial),[14] and in an open-label trial lasting 179 days published in 1993.[15]
The United States Air Force uses zolpidem as one of the hypnotics approved as "no-go pills" to help aviators and special duty personnel sleep in support of mission readiness. "Ground tests" are required prior to authorization being issued to use the medication in an operational situation.[16]
[edit]Brain injury
A case study performed at the Toulouse University Hospital using PET showed zolpidem repeatably improves brain function and mobility of a patient immobilized by akinetic mutism caused by hypoxia.[17]
Recently, zolpidem has been cited in various medical reports mainly in the United Kingdom as waking persistent vegetative state (PVS) patients, and dramatically improving the conditions of people with brain injuries.[18][19][20][21][22] Results from phase IIa trials were expected in June 2007. The trials are being conducted by Regen Therapeutics of the UK, who have a patent pending on this new use for Zolpidem.[23][24]
[edit]Coma
Zolpidem has recently been very strongly related to certain instances of patients in a minimally conscious coma state being brought to a fully conscious state. While it was initially given to these supposed permanent coma patients to put them to sleep, it actually brought them to a fully conscious state in which they were capable of communicating and interacting for the first time in years. CT scans have shown that the use of the drug actually does dramatically increase the activity in the frontal lobe of the brain in some patients in a minimally conscious state. Large-scale studies are currently being done to see whether it has the same universal effect on all or most patients in a minimally conscious state.[25] It may be that zolpidem's ability to stimulate the brain, particularly in the semi-comatose, may be related to one of its side-effects, which sometimes causes sleepwalking and other activity while asleep, that appears to observers to be fully conscious activity.
[edit]Miscellaneous off-label
Zolpidem is also used off-label to treat restless leg syndrome and as an antiemetic.
As is the case with many prescription sedative/hypnotic drugs, it is sometimes used by stimulant users to "come down" after the use of stimulants such as amphetamines (including methamphetamine), ? , and MDMA (ecstasy).[26]
[edit]Side effects

Side-effects at any dose may include:
Anterograde amnesia
Hallucinations, through all physical senses, of varying intensity
Delusions
Altered thought patterns
Ataxia or poor motor coordination, difficulty maintaining balance[27]
Euphoria and/or dysphoria
Increased appetite
Increased libido
Amnesia
Impaired judgment and reasoning
Uninhibited extroversion in social or interpersonal settings
Increased impulsivity
When stopped, rebound insomnia may occur
Headaches in some people
Memory loss in some people
A clinical trial found that after administration of zolpidem trial subjects tended to feel weak, fatigued and developed an antagonistic mood.[28]
Some users take zolpidem recreationally for some of these side-effects, notably sedation, hallucinations and euphoria. Zolpidem becomes addictive if taken for extended periods of time, due to drug tolerance and physical dependence or the euphoria it can sometimes produce. Under the influence of the drug, it is common for one to take more zolpidem than is necessary, due to either forgetting that one has already taken a pill (elderly users are particularly at risk here) or knowingly taking more than the prescribed dosage. The release of AmbienCR (zolpidem tartrate extended release) in the United States renewed interest in the drug among recreational drug users.
Some users have reported unexplained sleepwalking while using zolpidem, and a few have reported driving, binge eating, sleep talking, and performing other daily tasks while sleeping. Research by Australia's National Prescribing Service found that these events mostly occur after the first dosage taken or within a few days of starting therapy.[29] Rare reports of sexual parasomnia episodes related to zolpidem intake have also been reported.[30] The sleepwalker can sometimes perform these tasks as normally as they might if they were awake. They can sometimes carry on complex conversations and respond appropriately to questions or statements so much so that the observer may believe the sleepwalker to be awake. This is similar to, but unlike, typical sleep talking, which can usually be identified easily and is characterised by incoherent speech that often has no relevance to the situation or that is so disorganised as to be completely unintelligible. A person under the influence of this medication may seem fully aware of their environment even though they are still asleep. This can bring about concerns for the safety of the sleepwalker and others. These side-effects may be related to the mechanism that also causes zolpidem to produce its hypnotic properties.[31] It is unclear whether the drug is responsible for the behavior, but a class-action lawsuit was filed against Sanofi-Aventis in March 2006 on behalf of those that reported symptoms.[32]
Residual 'hangover' effects such as sleepiness, impaired psychomotor and cognitive after nighttime administration may persist into the next day which may impair the ability of users to drive safely, increase risks of falls and hip fractures.[33]
The Sydney Morning Herald in Australia reported in 2007 that a man who fell 30 meters to his death from a high-rise unit balcony may have been sleepwalking under the influence of Stilnox. The coverage prompted over 40 readers to contact the newspaper with their own accounts of Stilnox-related automatism, and as of March 2007, the drug was under review by the Adverse Drug Reactions Advisory Committee.[34]
In February 2008, the Australian Therapeutic Goods Administration attached a Black Box Warning to zolpidem, stating that "Zolpidem may be associated with potentially dangerous complex sleep-related behaviours which may include sleep walking, sleep driving and other bizarre behaviours. Zolpidem is not to be taken with alcohol. Caution is needed with other CNS depressant drugs. Limit use to four weeks maximum under close medical supervision."[35]This report received widespread media coverage[36]after the death of Australian student Mairead Costigan, who fell 20m from the Sydney Harbour Bridge while under the influence of Stilnox.[37]
[edit]Tolerance, dependence, and withdrawal



Ambien tablets
A review medical publication found that long term use of zolpidem is associated with drug tolerance, drug dependence, rebound insomnia and CNS related adverse effects. It was recommended that zolpidem be used for short periods of time using the lowest effective dose. Non-pharmacological treatment options however, were found to have sustained improvements in sleep quality.[38] Animal studies of the tolerance inducing properties have shown that in rodents zolpidem has less tolerance producing potential than benzodiazepines but in primates the tolerance producing potential of zolpidem was the same as that of benzodiazepines.[39] Tolerance can develop in some people to the effects of zolpidem in just a few weeks. Abrupt withdrawal of zolpidem may cause delirium, seizures or other severe effects, especially if used for prolonged periods and at high dosages.[40][41][42] When drug tolerance and physical dependence to zolpidem has developed, treatment usually entails a gradual dose reduction over a period of months in order to minimise withdrawal symptoms which can resemble those seen during benzodiazepine withdrawal. Failing that, an alternative method which may be necessary for some patients is a switch to a benzodiazepine equivalent dose of a longer acting benzodiazepine drug such as diazepam or chlordiazepoxide followed by a gradual reduction in dosage of the long acting benzodiazepine. Sometimes for difficult to treat patients an inpatient flumazenil rapid detoxification program can be used to detox from a zolpidem drug dependence or addiction.[43] However, it should be noted that this treatment approach closely parallels that of the highly controversial rapid ? detoxification therapy, which critics claim lacks long-term efficacy and can actually be detrimental to a patient's long-term recovery. Additionally, there have been many questions raised about the ethics as well as safety of rapid detox following a number of deaths resulting from the procedure.[44][45]
Alcohol has cross tolerance with GABAa receptor positive modulators such as the benzodiazepines and the nonbenzodiazepine drugs. For this reason alcoholics or recovering alcoholics may be at increased risk of physical dependency on zolpidem. Also, alcoholics and drug abusers may be at increased risk of abusing and or becoming psychologically dependent on zolpidem. Zolpidem should be avoided in those with a history of Alcoholism, drug misuse, or in those with history of physical dependency or psychological dependency on sedative-hypnotic drugs.
[edit]Special precautions

[edit]Driving
Use of zolpidem may impair driving skills with a resultant increased risk of road traffic accidents. This adverse effect is not unique to zolpidem but also occurs with other hypnotic drugs. Caution should be exercised by motor vehicle drivers.[46]
[edit]Elderly
The elderly are more sensitive to the effects of hypnotics including zolpidem. Zolpidem causes an increased risk of falls and may induce cognitive adverse effects.[47]

riddlerap

Mechanism of action


Due to its selective binding, Zolpidem has very weak anxiolytic, myorelaxant and anticonvulsant properties but very strong hypnotic properties.[49] Zolpidem binds with high affinity to the α1 containing GABAA receptors, about 10-fold lower affinity for those containing the α2 - and α3 - GABAA receptor subunits, and with no appreciable affinity for α5 subunit containing receptors.[50] ω1 type GABAA receptors are the α1 containing GABAA receptors and ω2 GABAA receptors are the α2, α3, α4, α5 and α6 containing GABAA receptors. ω1 GABAA receptors are primarily found in the brain whereas ω2 receptors are primarily found in the spine. Thus zolpidem has a preferential binding for the GABAA-benzodiazepine receptor complex in the brain but a low affinity for the GABAA-benzodiazepine receptor complex in the spine.[51]
Like the vast majority of benzodiazepine-like molecules, zolpidem has no affinity for α4 and α6 subunit-containing receptors.[52] Zolpidem positively modulates GABAA receptors, probably by increasing the GABAA receptor complexes apparent affinity for GABA, without affecting desensitization or peak current.[53] Zolpidem increases slow wave sleep and caused no effect on stage 2 sleep in laboratory tests.[54]
A meta-analysis of the randomised controlled clinical trials that compared benzodiazepines against Z-drugs such as zolpidem has shown that there are few consistent differences between zolpidem and benzodiazepines in terms of sleep onset latency, total sleep duration, number of awakenings, quality of sleep, adverse events, tolerance, rebound insomnia, and daytime alertness.[55]
[edit]Drug-drug interactions
Notable drug-drug interactions with the pharmacokinetics of zolpidem include the following drugs chlorpromazine, cimetidine, fluconazole, imipramine, itraconazole, ketoconazole, rifampicin, ritonavir. Interactions with carbamazepine and phenytoin can be expected based on their metabolic pathways but have not yet been studied.[56]
[edit]Overdose

An overdose of zolpidem may cause excessive sedation, pin-point pupils, depressed respiratory function, which may progress to coma and possibly death. Zolpidem combined with alcohol, opiates or other CNS depressants may be even more likely to lead to fatal overdoses. Zolpidem overdosage can be treated with the benzodiazepine receptor antagonist flumazenil, which displaces zolpidem from its binding site the benzodiazepine receptor and therefore rapidly reverses the effects of zolpidem.[57]
[edit]Recreational use

Zolpidem has a potential for either medical misuse when the drug is continued long term without or against medical advice, or recreational use when the drug is taken to achieve a high.[58] The transition from medical use of zolpidem to high dose addiction or drug dependence can occur when used without a doctor's recommendation to continue using it, when physiological drug tolerance leads to higher doses than the usual 5 mg or 10 mg, when consumed through insufflation or injection, or when taken for purposes other than as a sleep aid. Abuse is more prevalent in those that have been dependent on other drugs in the past, but tolerance and drug dependence can still sometimes occur in those without a history of drug dependence. Chronic users of high doses are more likely to have a severe physical dependence on the drug which may cause severe withdrawal symptoms including seizures if abrupt withdrawal from zolpidem occurs.[59]
One case history report involved a woman detoxing off a high dose of zolpidem experiencing a generalized seizure, with clinical withdrawal and dependence effects reported to be similar to the benzodiazepine withdrawal syndrome.[60]
In the U.S., recreational use of zolpidem is becoming more common. Recreational users claim that "fighting" the effects of the drug by forcing themselves to stay awake will sometimes cause vivid visuals and a body high.[citation needed] Some users report decreased anxiety, mild euphoria, perceptual changes, visual distortions, and hallucinations.[61]
Zolpidem can be used to facilitate sexual assault.[62][63]
Zolpidem and other sedative hypnotic drugs are detected frequently in cases of people suspected of driving under the influence of drugs. Other drugs including the benzodiazepines and zopiclone are also found in high numbers of suspected drugged drivers. Many drivers have blood levels far exceeding the therapeutic dose range suggesting a high degree of excessive-use potential for benzodiazepines, zolpidem and zopiclone.[64] U.S. Congressman Patrick J. Kennedy says that he was using Zolpidem (Ambien) and Phenergan when caught driving erratically at 3AM. [65] "I simply do not remember getting out of bed, being pulled over by the police, or being cited for three driving infractions," Kennedy said.
As Ambien's patent expired April 21, 2007, 13 new generic versions were approved, which do not have the "protective cover" present on the Sanofi name-brand Ambien they once previously had to prevent users from crushing, snorting, or injecting the drugs.[citation needed]

[Deleted User]

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riddlerap

can you drool into my mouth?

riddlerap

thats so damn hot

[Deleted User]

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riddlerap

oh ok dude cool story

SunflowaSeeds

https://www.youtube.com/watch?v=Dy6VJhfxxEM

so refreshing

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SunflowaSeeds

Booooooooooooooooooo

riddlerap

Lollllllllllllllllllllllllll

Tha Chop

try 2 grams of blow and 160 mg's of oxycontin up the nose.

BRiCKSQUAD

lmao...................................................rofl......................................lol............................ROFLMAOLOL

Drugaddiction

As a drug is by definition the World Health Organisation (WHO) any substance that is able to change in a living organism functions and no food is. In everyday use the term drug in us - in contrast to the Anglo-Saxon countries, where, with common drugs as defined by the WHO medicines are known (see Drug (Pharmacy)) - broad, tighter: Drugs are substances and preparations, primarily an intoxicant to the generating a noise condition or the emergence of a dependency syndrome (colloquially a "Seek") lead. In this case, drug awareness and changing the perception of consumers during their impact, and beyond.
Drug Addiction
The world's most widely used drugs are caffeine (in coffee), nicotine (in tobacco), alcohol, betel and cannabis. Tobacco and alcohol reported that most casualties. A listing of all common drugs, including typical scene expressions is found in the drug glossary.
Did not know this til now...

b@squ1@t redux

It would be my first time trippin.we had gotten the shrooms the day before. I have no idea how much i took in measures.i ate two litlle baggies.each had two caps and three stems.i used the orange juice trick to get them down.i thought they didn't taste so bad.about a hour after eaten the things.i started to fell a body buzz.the 10 minutes later it hit.every thing seemed really weird.my friend had this really crazy lookin gorilla head that was made from a coconut husk.i played with it for a while.then it got this really big grin on it,that freaked me out so i threw it.the five of us guys decided we wre hungry.so we went down to the kitchen.i looked in the frig,there was nothing ther to eat.so i told my friend that i was hungry and that i wanted sushi.so i stuck my hand in his aqurium and tried to eat his goldfish.i missed three times in a row so i gave up.i returned to the living and got into a fight over jello.in the end i split it with one off my friends.we returned to the bedroom where i just sat on the floor.i looked at my friends wood panel door,and saw faces crying out for help and blood seeping underneath his door.thus was really cool looking to me.then one of my calle dhis girlfriend,while he rolled a joint.he talked they passed it around.i only took two hits.then i remember making a comment about how his girlfriend wears a size 0.because she does.then he got really mad and wanted to fight.[he was just ? with me but at the time i thought he was serious].then me and one of the other guys deciced to go for a walk.we went outside,and the trees were looming in on me.and there were all these people looking at us.i was thinking to myself,it is 1:oo a.m ,what are all these people doing out here.we walked for what seemed like a hour,but we wre only 5 feet away from the house.then i saw a dead midget in a tuxedo,behind my friends house.i felt sad then.the rest of the night was a blur.i remember getting everyone to smell my finger.[because i had fingered my girlfrien earlier theat night].one guy played along ,and said it smell like butterscotch.[if anyone has seen the movie 'kids' then they get the joke].in all it was a great night that i will always remember.i can't wait to the next trip. Peace. Life is to short so love the one ya got-

fiat_money

Word, I don't ? with that "medicine" ? .

MsSouthern

Seedz


Don't do that again !!!

Drugaddict

Well this is my new blog about addiction to drugs...
Drug addiction

Things I think are worth the read, especially for Parents...
So tell me what you think about it...
And sorry i did not find suitable category for this post...

ignas762

My wife has been on generic ambien medication for years now and cannot fall asleep without it now. However, she does get a good night's sleep without any side effects. I'm now going to try it. I've had a couple of her pills and they worked well for me.

Yung_Souf_Money

wtf is going on?